Harmony Prenatal Test : a simple blood test to detect common fetal trisomies.
Test Sampling
Method		 Benefits Limtations
Screening tests:
maternal serum
screening and
ultrasound		 Non-invasive
blood draw, nuchal translucency
  • Safe; very low risk
    to mother or fetus
  • Reasonable cost
  • Testing can involve multiple visits
  • Multistep protocols with narrow timelines for effective patient management
  • Up to 5% false-positive rate
  • Up to 30% false-negative rate
Chromosome analysis Invasive (amniocentesis; CVS; chorionic villus sampling)
  • >99% diagnostic accuracy with amniocentesis
  • Highly accurate results with CVS
  • Risk of fetal loss
  • Potential for maternal complications
  • High cost to the healthcare system
First-generation
DNA tests (shotgun sequencing)		 Non-invasive
blood draw
  • Accurate
  • Safe
  • High economic cost
  • Likely limited to trisomy detection only
Harmony Prenatal Test (directed DNA analysis) Non-invasive
blood draw
  • Accurate
  • Safe
  • Efficient and affordable
  • Individualized quantitative result
  

Prenatal trisomy testing methods can lead to clinical challenges

Tests for fetal trisomies fall into one of three broad categories—screening tests, invasive tests, and non-invasive DNA-based detection. All have their strengths and limitations.

The non-invasive Harmony Prenatal Test for fetal trisomies is simple, safe, accurate, and affordable.